i got it running just yesterday. it runs flawlessly. but it did need a little bit of tweaking.
when the game came out, people soon found out that they saw through walls. the alt-tab trick fixed that (alt-tab to windows and back, and you have your walls back).

i am running windows 2000 professional + SP4, and amigamerlin 3.0 driverset.

when i installed renegade yesterday, i tried i at the very lowest resolution first. i used the alt-tab trick, but still ad an enormous flicker problem. luckily, 3Danalyze has a "Voodoo Flicker Fix" option. total stable image after using 3danalyze.
i then upped the resolution to 1024x768 and 2xfsaa and maximum settings... still smooth as silk, its just i could see through wall again... alt-tabbed like ten times, only to find out i had to lower the detail settings a bit for the alt-tab trick to work.
also, 2x fsaa slowed down a lot when i zoomed in with the sniper rifle.
so:
alt-tab back and forward to fix the see-trough-walls-problem
use 3danalyze flicker fix to fix the flickery image
dont use maximum detail settings (will try to find the exact option)